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Antihemophilic Factor/von Willebrand Factor Complex (Human)


Related terms
Author information


    Related terms
    • U.S. Brand Names: Alphanate® ;Humate-P®;Wilate®
    • Canadian Brand Names: Humate-P®
    • Pharmacologic Category: Antihemophilic Agent;Blood Product Derivative

    • It is used to treat hemophilia.
    • It is used to treat von Willebrand disease.
    • It is used to stop and treat bleeding.
    • Antihemophilic factor/von Willebrand factor complex (human) replaces proteins to stop bleeding.


    How to take

    • It is given as a shot into a vein.
    • This drug can be given at home.
    • Your doctor may teach you how to give the shot.
    • Wash your hands before and after use.
    • Throw away needles in a needle/sharp disposal box and take the box back to your doctor when it is full.


    • Most of the time, this drug will be given to you in a doctor's office. You will not store it at home.
    • If this drug is given at home, store unopened vials in a refrigerator. Do not freeze.
    • Humate-P®: May also store unopened vials at room temperature. Throw away any unused vials after date on bottle has passed.
    • Alphanate®: Or store unopened vials at room temperature. Throw away any unused vials after 2 months.
    • Wilate®: Or store unopened vials at room temperature. Throw away any unused vials after 6 months.



    • If you have an allergy to antihemophilic factor/von Willebrand factor complex (human) or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


    • Wear disease medical alert ID (identification).
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Short-term pain after use.
    • Allergic reactions can rarely happen.
    • Gallbladder disease, blood clots, heart attacks, and other blood vessel problems can rarely happen.


    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Trouble breathing.
    • Chest pain or pressure.
    • Change in thinking clearly and with logic.
    • Change in strength on one side greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Weakness, numbness, or tingling.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. You may also call the FDA at 1-800-FDA-1088 or Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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