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Table of Contents > Drug > Amlodipine, Valsartan, and Hydrochlorothiazide Print

Amlodipine, Valsartan, and Hydrochlorothiazide

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Exforge HCT®
    • Pharmacologic Category: Angiotensin II Receptor Blocker;Antianginal Agent;Calcium Channel Blocker;Calcium Channel Blocker, Dihydropyridine;Diuretic, Thiazide

    Uses
    • It is used to treat high blood pressure.
    • It is used to get rid of extra fluid.
    • Amlodipine calms blood vessels, lowering blood pressure.
    • Valsartan lowers blood pressure by lowering a strong chemical in the body.
    • Hydrochlorothiazide (HCTZ) lowers blood pressure and gets rid of extra salt and water in the body.

    Dosing

    How to take

    • Take as you have been told, even if you are feeling better.
    • Take this drug at the same time of day.
    • Take early in the day to stop sleep problems.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Follow the diet and workout plan that your doctor told you about.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • Do not take if you are pregnant. Use during pregnancy may cause birth defects. If you get pregnant or plan on getting pregnant while taking this drug, call your doctor right away.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to amlodipine, valsartan, hydrochlorothiazide, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have a sulfa (sulfonamide) allergy, talk with your doctor.
    • If you have a block in the kidneys' arteries or other kidney disease.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • Wear disease medical alert ID (identification).
    • Do not run out of this drug.
    • If you have high blood sugar (diabetes), this drug may sometimes raise blood sugar. Talk with your doctor about how to fine tune this.
    • If you have liver disease, talk with your doctor.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • If you are taking a salt substitute that has potassium, potassium-sparing diuretics, or potassium, talk with your doctor.
    • Talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
    • Avoid grapefruit and grapefruit juice.
    • Limit your drinking of wine, beer, or mixed drinks.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Be careful in hot weather. Drink lots of fluids to stop fluid loss.
    • Watch for gout attacks.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • High potassium level. Signs include feeling weak, lightheaded, dizzy, feel like passing out, or have numbness or tingling.
    • Low potassium levels. Signs include feeling tired, weak, numbness, or tingling; muscle cramps; hard stools (constipation); throwing up; or a fast heartbeat.
    • Headache.
    • Swelling.
    • Cough.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.
    • Kidney function that gets worse.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • A fast heartbeat.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Signs of high potassium.
    • Signs of low potassium.
    • Cough that does not go away.
    • Too much sweat, fluid loss, throwing up, or loose stools. May lead to low blood pressure.
    • Not able to pass urine.
    • Sudden change in eyesight, eye pain, or irritation.
    • For women, if you get pregnant while taking this drug.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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