David's Natural Market is a health food retailer serving the Columbia community.
Table of Contents > Drug > Estradiol (Systemic) Print

Estradiol (Systemic)

Image

Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Alora®;Climara®;Delestrogen®;Depo®-Estradiol;Divigel®;Elestrin®;Estrace®;Estraderm®;Estrasorb®;EstroGel®;EvamistT;Femring®;Femtrace®;Menostar®;Vivelle-Dot®
    • Brand Names: Canada: Climara®;Depo®-Estradiol;Estraderm®;Estradot®;EstroGel®;Menostar®;Oesclim®;Sandoz-Estradiol Derm 100;Sandoz-Estradiol Derm 50;Sandoz-Estradiol Derm 75
    • Pharmacologic Category: Estrogen Derivative

    Uses
    • It is used to put off soft, brittle bones (osteoporosis) in women after change of life.
    • It is used to stop or lower the signs of stopping periods (menopause).
    • It is used when the ovaries have been taken out, are not working the right way, or have stopped working.
    • Rarely, it is used to treat breast or prostate cancers.
    • Estrogens are used to add estrogen to the body.
    • It lowers bone loss.

    Dosing

    How to take

    • Shot:
    • It is given as a shot into a muscle.
    • Oral:
    • Take this drug at the same time of day.
    • There may be days when you will not take this drug.
    • Take this drug with food.
    • Soft, brittle bones (osteoporosis):
    • This drug works best when used with calcium/vitamin D and weight-bearing workouts like walking or PT (physical therapy).
    • Follow the diet and workout plan that your doctor told you about.
    • Skin emulsion:
    • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
    • Put on clean, dry, healthy skin.
    • Put contents of 1 pouch on 1 thigh. Rub into thigh and calf.
    • Put contents of the second pouch on the other thigh. Rub into thigh and calf.
    • Put any emulsion left on your hands on the buttocks.
    • Wash your hands after use.
    • Let dry before covering with clothing.
    • Skin gel:
    • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
    • Divigel®:
    • Put on clean, dry, healthy skin on the thigh.
    • Move the site with each packet.
    • Do not put on the face, breast, or vagina.
    • Put over 5 x 7 inches.
    • Wash your hands after use.
    • Do not bathe, shower, or swim for 1 hour after putting on.
    • Let dry before covering with clothing.
    • EstroGel®:
    • Prime pump before first use.
    • Put on clean, dry, healthy skin of 1 arm from the wrist to the shoulder.
    • Put on gel at the same time of day.
    • Do not bathe, shower, or swim right after putting on.
    • Wash your hands after use.
    • Let dry before covering with clothing.
    • Avoid fire, flames, or smoking until the gel has dried.
    • Elestrin®:
    • Prime pump 10 times before use.
    • Put on clean, dry, healthy skin of upper arm and shoulder.
    • Bathe or shower before putting on.
    • Do not swim for 2 hours after putting on.
    • Skin patch:
    • Put patch on clean, dry, healthy skin. Move the site with each new patch.
    • Do not place on breast.
    • Skin spray:
    • Prime pump by spraying it 3 times.
    • Hold container upright and rest plastic cone flat on the skin while spraying.
    • Put on clean, dry, healthy skin of the inner forearm. Start near the elbow.
    • Use spray at the same time of day.
    • Let dry before covering with clothing.
    • Do not rub into skin.
    • Do not bathe, shower, or swim for 1 hour after putting on.
    • Avoid fire, flames, or smoking until dry.
    • Vaginal ring:
    • Put into the vagina and leave in place for 90 days.
    • Follow how to use as you have been told by your doctor or read the package insert.
    • Take out ring at the start of the 13th week.
    • Put in a new ring.
    • To use, wash your hands and take ring from the pouch.
    • Press sides of ring at the same time between thumb and index finger and put folded ring into the vagina.
    • Perfect placement is not needed for the ring to work. The ring will not hurt.
    • To take off, hook your index finger around the rim or hold rim between index finger and middle finger and pull out.
    • Do not throw the vaginal ring in the toilet.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not use 2 doses or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.
    • Skin patch:
    • Put on a missed patch as soon as you think about it after taking off the old one.
    • Start a new timetable after the patch is put back in.
    • Do not put on 2 doses or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect tablets from water. Do not store in a bathroom or kitchen.
    • Shot:
    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.

    Safety



    Warnings

    • Estrogens, when used in women after stopping periods (menopause), may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
    • Do not take estrogens if you are pregnant. If you get pregnant while taking this drug, call your doctor right away.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.
    • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
    • Do not let any other person touch the spray or the treated part of your skin.

    Avoid

    • If you have an allergy to estradiol or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Blood clots, breast cancer (except in some cases where the cancer has spread), liver disease, recent heart attack, recent stroke, tumor where estrogen makes it grow, or vaginal bleeding.
    • If you have surgery and need bed rest.
    • If you are pregnant or may be pregnant.

    Precautions

    • If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.
    • There may be a higher chance of endometrial or breast cancer.
    • If you have asthma, talk with your doctor.
    • If you have any blood flow problems, talk with your doctor.
    • If you have gallbladder disease, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have high calcium levels, talk with your doctor.
    • If you have had high triglyceride levels, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have migraine headaches, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Have an eye exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take St John's wort, dong quai, black cohosh, saw palmetto, red clover, or ginseng with this drug.
    • Avoid cigarette smoking. People older than 35 years of age and/or smoking more than 15 cigarettes per day have more chance for heart disease.
    • Limit your drinking of wine, beer, or mixed drinks.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Tell your doctor if you are breast-feeding.
    • Skin emulsion:
    • Do not use sunscreen on legs before using emulsion or soon after using emulsion.
    • Skin gel:
    • Do not use sunscreen before using gel or soon after using gel.
    • Do not use sunscreen on gel part for 7 days in a row.
    • Skin spray:
    • Use sunscreen 1 hour before using spray.
    • If a child touches the spray, she/he needs to wash the skin with soap and water.
    • Skin patch:
    • The patch may have metal. Take off the patch before an MRI.

    Side Effects

    • Headache.
    • Belly pain.
    • Hair loss.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Swelling.
    • Enlarged breasts.
    • Skin irritation.
    • Change in sex ability. This most often goes back to normal.
    • For women, vaginal yeast infection. Report itching or discharge.
    • Gallbladder disease, blood clots, heart attacks, and other blood vessel problems may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure.
    • Trouble breathing.
    • Swelling or pain in the leg or arm.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Not able to eat.
    • Very bad skin irritation.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Change in how contact lenses feel in the eyes.
    • A lump in the breast or breast soreness.
    • Signs that your child was exposed to the spray. These include early puberty and enlarged sex organs.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

    Search Site

    Now Solutions
    Eden Foods
    Naturtint
    Lily of the Desert
    Wakunaga of America
    Olbas
    Eden Foods
    Almased
    American Health