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Table of Contents > Drug > Tacrolimus (Systemic) Print

Tacrolimus (Systemic)

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Prograf®
    • Brand Names: Canada: Advagraf®;Prograf®
    • Pharmacologic Category: Calcineurin Inhibitor;Immunosuppressant Agent

    Uses
    • It is used to keep the body from turning down the organ after an organ transplant.
    • It is used to treat diseases of the immune system.
    • Tacrolimus helps the body accept an organ transplant.
    • It lowers the body's harmful response to diseases of the immune system.

    Dosing

    How to take

    • Oral:
    • Take with or without food. Always take with food or always take on an empty stomach.
    • Swallow whole. Do not chew, break, or crush.
    • Follow the diet and workout plan that your doctor told you about.
    • Shot:
    • It is given as a shot into a vein over a period of time.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.
    • The shot will be given to you in a hospital or doctor's office. You will not store it at home.

    Safety



    Warnings

    • Long-term use may raise the chance of cancer and unsafe infections.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to tacrolimus or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are breast-feeding.

    Precautions

    • The chance of cancer is higher after using this drug.
    • If you have high blood pressure, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take antacids, cholestyramine, or colestipol within 2 hours of this drug.
    • Avoid grapefruit and grapefruit juice.
    • Avoid beer, wine, or mixed drinks.
    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of a very bad infection or make the vaccine not work as well.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Tell your doctor if you are pregnant or plan on getting pregnant.

    Side Effects

    • High blood pressure.
    • Kidney function that gets worse.
    • Chance of getting an infection. Avoid people with infections, colds, or flu.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools.
    • Not able to sleep.
    • Sunburn.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Very bad headache.
    • Any bruising or bleeding.
    • More trips to the bathroom, more thirst, or weight loss.
    • Not able to pass urine.
    • Very bad swelling.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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