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Table of Contents > Drug > Atovaquone and Proguanil Print

Atovaquone and Proguanil

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • U.S. Brand Names: Malarone®
    • Canadian Brand Names: Malarone®;Malarone® Pediatric
    • Pharmacologic Category: Antimalarial Agent

    Uses
    • This medicine is used to prevent or treat malaria.
    • Atovaquone and proguanil work to injure the parasite and fight the infection.

    Dosing

    How to take

    • This medicine should be started before travel to the high risk area. Continue use after leaving the area.
    • To gain the most benefit, do not miss doses.
    • Use prescription as directed, to prevent malaria.
    • Take this medicine at a similar time of day.
    • Take this medicine with food.
    • If you vomit within 1 hour of taking this medicine, take another dose.
    • May crush tablet and mix with milk.

    Missed Dose

    • Take a missed dose as soon as possible.
    • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
    • Do not take a double dose or extra doses.
    • Do not change dose or stop medicine. Talk with healthcare provider.

    Storage

    • Store at room temperature.
    • Protect from moisture. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.

    Avoid

    • If you have an allergy to atovaquone, proguanil, or any other part of this medicine.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
    • If you are using this medicine to prevent malaria and have severe kidney disease.

    Precautions

    • If you have kidney disease, talk with healthcare provider.
    • If you have liver disease, talk with healthcare provider.
    • Other protective measures are needed along with this medicine including using screens, bednetting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Decrease evening and night-time outdoor activity.
    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Tell healthcare provider if you are pregnant or plan on getting pregnant.
    • Pregnant females traveling to malaria infested areas should discuss the risks with a healthcare provider first.
    • Tell healthcare provider if you are breast-feeding.

    Side Effects

    • Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
    • Headache.
    • Belly pain.
    • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Diarrhea.

    Monitoring

    • Change in condition being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Fever that occurs while in or after return from the malaria area.
    • Severe nausea or vomiting.
    • Severe diarrhea.
    • Any rash.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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