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Imipenem and Cilastatin


Related terms
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    Related terms
    • U.S. Brand Names: Primaxin® I.M. [DSC];Primaxin® I.V.
    • Canadian Brand Names: Imipenem and Cilastatin for Injection;Primaxin® I.V. Infusion;RANT-Imipenem-Cilastatin
    • Mexican Brand Names: Arzobema;Iminen;Tienam
    • Pharmacologic Category: Antibiotic, Carbapenem

    • It is used to treat bacterial infections.
    • Imipenem and cilastatin work to harm the bacteria and fight the infection.


    How to take

    • It is given as a shot into a vein.

    Missed Dose

    • Call doctor to find out what to do.


    • This drug will be given to you in a doctor office setting. You will not store it at home.



    • This drug does not mix well with some drugs. Not safe reactions may happen. Check all drugs with doctor.


    • If you have an allergy to imipenem, cilastatin, or any other part of this drug.
    • Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.


    • If you have kidney disease, talk with doctor.
    • If you have seizures, talk with doctor.
    • Check drugs with doctor. This drug may not mix well with other drugs.
    • Tell doctor if you are pregnant or plan on getting pregnant.
    • Tell doctor if you are breast-feeding.

    Side Effects

    • Upset stomach or throwing up. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools. Yogurt, Bifidobacterium bifidum, or Lactobacillus acidophilus may help. You can get these products at health food stores or in some pharmacies.
    • For women, vaginal yeast infection. Report itching or discharge.
    • Seizures can rarely happen.


    • Change in health problem being treated. Is it better, worse, or about the same?
    • For unwanted reactions to the drug.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Very upset stomach or throwing up.
    • Very bad loose stools, even after drug is stopped.
    • Big change in thinking clearly and with logic.
    • Feeling very tired or weak.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list your doctor.
    • Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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