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Related terms
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    Related terms
    • U.S. Brand Names: Constulose;Enulose;Generlac;Kristalose®
    • Canadian Brand Names: Acilac;Apo-Lactulose®;Laxilose;PMS-Lactulose
    • Mexican Brand Names: Lactulax;Regulact
    • Pharmacologic Category: Ammonium Detoxicant;Laxative, Osmotic

    • This medicine is used to prevent or treat changes in thinking caused by severe liver disease.
    • This medicine is used to treat constipation. It may take 1-2 days to see the full effect.
    • Lactulose decreases absorption of toxins into the system.
    • It softens the stool by increasing its water content.


    How to take

    • Take this medicine with or without food. Take with food if it causes an upset stomach.
    • Take this medicine with a full glass of water.
    • Mix with juice, milk, water, or sweet foods to improve taste.
    • Those who have feeding tubes can also use the liquid. Dilute with water first. Flush the feeding tube before and after medicine is given.
    • If for constipation, drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.

    Missed Dose

    • Take a missed dose as soon as possible.
    • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
    • Many times this medicine is taken on an as needed basis.


    • Store at room temperature. Do not freeze.



    • If you have an allergy to lactulose or any other part of this medicine.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
    • If you are on a low-galactose or lactose-free diet.
    • If you are taking other laxatives.


    • If you have diabetes, talk with healthcare provider.
    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Do not take antacids with this medicine.
    • Tell healthcare provider if you are pregnant or plan on getting pregnant.
    • Tell healthcare provider if you are breast-feeding.

    Side Effects

    • Belly pain or heartburn.
    • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Diarrhea.


    • Change in condition being treated. Is it better, worse, or about the same?
    • Follow up with healthcare provider.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Severe dizziness or passing out.
    • Severe diarrhea.
    • Severe belly pain.
    • Any rash.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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