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Table of Contents > Drug > Carbidopa and Levodopa Print

Carbidopa and Levodopa

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Parcopa®;Sinemet®;Sinemet® CR
    • Brand Names: Canada: Apo-Levocarb®;Apo-Levocarb® CR;Dom-Levo-Carbidopa;DuodopaT;Endo®-Levodopa/Carbidopa;Levocarb CR;Novo-Levocarbidopa;Nu-Levocarb;PRO-Levocarb;Sinemet®;Sinemet® CR
    • Mexican Brand Names: Racovel;Sinemet
    • Pharmacologic Category: Anti-Parkinson's Agent, Decarboxylase Inhibitor;Anti-Parkinson's Agent, Dopamine Precursor

    Uses
    • It is used to treat Parkinson's disease.
    • It is used to treat restless leg syndrome.
    • Levodopa and carbidopa helps keep chemical balance in the brain.

    Dosing

    How to take

    • Take with or without food. Take with food if it causes an upset stomach.
    • Avoid a high protein diet.
    • Oral-disintegrating tablet: Place on your tongue and let it melt. Do not swallow it whole.
    • Long-acting products: Swallow whole or as a half. Do not chew or crush.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take long-acting products more often than every 6 hours unless told to do so by your doctor.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from light.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Avoid

    • If you have an allergy to levodopa, carbidopa, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Glaucoma, melanoma, or skin spots.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.

    Precautions

    • If you have PKU, talk with your doctor. Some products have phenylalanine.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
    • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Big change in balance.
    • Change in thinking clearly and with logic.
    • Very upset stomach or throwing up.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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